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PROMISS Project: Work performed from the beginning of the project until 2019 March

Within the PROMISS consortium, low protein intake is considered a relevant marker of being at higher risk of developing protein-energy malnutrition. Results using meta-analysis of results from five international aging cohorts and three national surveys showed that the prevalence of low protein intake in older Europeans is substantial. Predictors of higher protein intake that were identified were: being female, having higher energy intake and higher tooth count, whilst significant predictors of lower protein intake included drinking alcohol and having swallowing problems. Importantly, PROMISS showed in multiple prospective studies that a lower protein intake in older persons is associated with increased risk of developing persistent protein-energy malnutrition and mobility limitations, poorer disability trajectories, lower grip strength and poorer physical performance compared to those with a higher protein intake, although no differences in change in muscle mass were observed. PROMISS also showed a high prevalence of poor appetite in older persons, and a different intake of food groups (including a lower overall protein intake) in persons with a poor appetite as compared to those with a good appetite - independent of their overall lower energy intake. The PRO55+ screening tool was developed as a research tool to efficiently identify older adults with a high risk for low protein intake (

A web-based survey among 1825 older adults from five European countries shows that the stratum of older adults with a poor appetite and lower level of protein intake (12.2%) is characterized by a larger share of people aged 70 years or above, living in the UK or Finland, having an education below tertiary level, who reported some or severe financial difficulties, having less knowledge about dietary protein and being fussier about food. This stratum also tends to have a higher risk of malnutrition in general, oral-health related problems, experience more difficulties in mobility and meal preparation, lower confidence in their ability to engage in physical activities in difficult situations, and a lower readiness to follow dietary advice. We are currently analyzing the oral and gut microbiome of a large sample of older adults wellcharacterized according to (long-term) weight change history, appetite, diet, taste and smell, in order to explore underlying pathways towards malnutrition. A database was developed including the environmental impact of 93 food products on carbon footprint, land occupation and fossil depletion and is currently being used to optimize potential dietary strategies for increasing protein intake in older adults with regard to environmental burden and meeting other dietary requirements and guidelines.

The industry/SME partners of PROMISS in collaboration with applied sciences universities have developed novel food concepts and food products for older adults, of which some are currently tested in a two-center, randomized controlled trial with a 6-month duration investigating the effect of different dietary strategies on the prevention of malnutrition and enhance active and healthy aging. Different variants of persuasive technology helping the older person to optimally adhere to the dietary strategies are also tested in this trial.


Ref. Ares(2019)5259882 - 15/08/2019